The aim of this study is to examine the association between depression and outcomes, such as mortality and intensive care admission, in Veterans who are hospitalised with pneumonia.
Major depressive disorder (“depression”) has been identified as an independent risk factor for mortality for many comorbid conditions, including heart failure, cancer and stroke. Major depressive disorder has also been linked to immune suppression by generating a chronic inflammatory state. However, the association between major depression and pneumonia has not been examined. The aim of this study was to examine the association between depression and outcomes, including mortality and intensive care unit admission, in Veterans hospitalized with pneumonia. Materials and Methods We conducted a retrospective national study using administrative data of patients hospitalized at any Veterans Administration acute care hospital. We included patients ≥65 years old hospitalized with pneumonia from 2002-2012. Depressed patients were further analyzed based on whether they were receiving medications to treat depression. We used generalized linear mixed effect models to examine the association of depression with the outcomes of interest after controlling for potential confounders.
DeWaters, Ami L. ; Chansard, Matthieu ; Anzueto, Antonio ; Pugh, Mary Jo ; Mortensen, Eric M. (2018). The Association Between Major Depressive Disorder and Outcomes in Older Veterans Hospitalized With Pneumonia. American journal of the Medical Sciences. Vol: 355 (1), p.21-26.