Mild Traumatic Brain Injury

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  • #5462

    We have just completed our first review report on mild Traumatic Brain Injury (mTBI) in Service Personnel.
    This report analyses:
    -the definition and classification of the condition.
    -its prevalence rates, specifically in relation to the US, the UK and Canada.
    -its markers and long-term consequences.
    -its comorbidity with other disorders.
    -approaches towards treatment.
    The report can be accessed here: https://hvrtmacveteranshealthdotorg.files.wordpress.com/2017/01/mtbi-report.pdf
    Do get in touch if you would like any further information or if you have any questions.

    #15008

    Hello,

    Does anyone have [F-18]FDDNP-PETscan data on TBI/CTE for Veterans? Or even any functional imaging for complex PTSD cases, which may be PTSD and/or TBI?

    Thank you

    #16378

    Hi Renata,
    In case you thought you were being ignored here is some info. you probably already know of these sources but here goes anyway:
    1. Traumatic Brain Injury (TBI) – research.va.gov
    http://www.research.va.gov/topics/tbi.cfm
    Ongoing large-scale initiatives designed to improve the health of Veterans with TBI include the Traumatic Brain Injury Veterans Health Registry and the “New Generation” study. The TBI VeteransHealth Registry, begun in 2009 by VA’s Office of Public Health (OPH), is providing military and civilian researchers with data on a large number of well …
    2. New CTE Study Categorizes Stages of … – U.S. Medicine
    http://www.usmedicine.com/agencies/department-of-veterans…
    Much time and data has been lost as veterans have been cast off when their symptoms did not fit into the neat little boxes the VA had ordered for them or proper lesions did not show clearly enough on CT scans, Said soldiers were often tossed out of TBI clinics and sent to mental health treatment due to the elusiveness of the physical evidence…
    3. In vivo characterization of chronic traumatic encephalopathy …
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413350
    Our initial [F-18]FDDNP PET studies in war veterans and other severe TBIs (n = 8) seem to indicate that blast-induced concussions present with a different neuropathology deposition profile than that found in blunt-force TBI or contact-sport–related concussions.
    4. In vivo characterization of chronic traumatic encephalopathy …
    http://www.pnas.org/content/112/16/E2039
    Mild traumatic brain injuries are frequent events in the general population and are associated with severe neurodegenerative disease, chronic traumatic encephalopathy (CTE). This disease is characterized by abnormal accumulation of protein aggregates, primarily tau proteins, which accumulate in …
    5. FDDNP-PET Tau Brain Protein Binding Patterns in Military …
    http://www.researchgate.net/publication/326456154_FDDNP…
    Request PDF on ResearchGate | FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy1 | Background: Our group has shown that in vivo tau …
    6. VA Screwing TBI Vets – Get These Quick Facts For Your TBI …
    http://www.disabledveterans.org/2014/05/16/va-screwing…
    Yet another was knocked unconscious for 30 days by an improvised explosive device (IED) and had a Glasgow Coma Score of 3 – the score does not go any lower – he has a TBI rating of 10%.
    7. Military-related traumatic brain injury and neurodegeneration
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255273
    Mild traumatic brain injury (mTBI) includes concussion, sub concussion, and most exposures to explosive blast from improvised explosive devices. mTBI is the most common traumatic brain injury affecting military personnel; however, it is the most difficult to diagnose and the least well understood. It …
    8. Veterans with TBI – How to Get Secondary Service Connection …
    http://www.hillandponton.com/tbi-secondary-service…
    Evidence does not have to be from the exact time of the TBI injury, but it does need to relate to the condition of TBI at or shortly after the time of the injury. An Example A Gulf War veteran submits his claim for service connection for Parkinsonism secondary to his service-connected TBI.
    9. Traumatic brain injury (TBI) – Health services research
    http://www.hsrd.research.va.gov/research_topics/tbi.cfm
    Citations. The Impact of Stigma on Community Reintegration of Veterans With Traumatic Brain Injury and the Well-Being of Their Caregivers. Archives of physical medicine and rehabilitation. 2018 May 3; pii: S0003-9993 (18):30277-6.

    #16421

    Thanks for sharing these references, Jim – I’ll make sure these are also included in the Hub’s repository.

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